6-(2-fluorophenyl)-7-iodo-5H-pyrrolo[3,2-d]pyrimidine → 6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carbonitrile

Participants

Reaction Steps

6-(2-fluorophenyl)-7-iodo-5H-pyrrolo[3,2-d]pyrimidine and CuCN in DMF were heated for 30 min at 175° C. in a microwave vial. The reaction mixture was filtered through a metal scavenging resin column, rinsed with DMF (˜10 mL), and purified by HPLC (10-75% MeCN/H2O with 1% formic acid) to give 29 mg of desired (17% yield). LC-MS calculated for C13H7FN4: 238.2, found 239.09 [M+H]+.

Provenance & Evidence