6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine → 3-[5-(2,4-Bis-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-6-(2-fluorophenyl)-3H-pyrrolo[3,2-d]pyrimidine

Participants

Reaction Steps

Prepared analogously to the method described for 3-[5[(4-methoxy-2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-ylmethyl]-6-(2-fluorophenyl)-3H-pyrrolo[3,2-d]pyrimidine beginning with 6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine (200 mg, 0.93 mmol) and methanesulfonic acid [5-(2,4-bis-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-yl]-methanyl ester (568 mg, 1.40 mmol) which produced 9 mg (5%) of the title compound. LCMS calculated for C23H12F7N5S: 523.4, found 524.01 (M+H)+.

Provenance & Evidence