3-(2,4-Bis-trifluoromethyl-phenyl)-6-chloromethyl-pyridazine → 2-[6-(2,4-Bis-trifluoromethylphenyl)-pyridazin-3-ylmethyl]-6-(2-fluorophenyl)-2H-pyrrolo[2,3-c]pyridazine

Participants

Reaction Steps

Prepared analogously to the method described for 2-[5[(4-methoxy-2-trifluoro-methylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-6-(2-fluorophenyl)-2H-pyrrolo[2,3-c]pyridazine beginning with 6-(2-fluorophenyl)-7H-pyrrolo[2,3-c]pyridazine (50 mg, 0.234 mmol) and 3-(2,4-Bis-trifluoromethylphenyl)-6-chloromethylpyridazine (95 mg, 0.27 mmol) to produce the titled compound (21.6 mg, 18%). 1H-NMR: (d6-DMSO, 400 MHz) δ 8.78 (d, 1H), 8.38 (dt, 1H), 8.21 (d, 2H), 8.02 (d, 1H), 7.95 (d, 1H), 7.89 (d, 1H), 7.86 (d, 1H), 7.47 (m, 1H), 7.31 (m, 2H), 7.12 (d, 1H), 6.22 (s, 2H). LCMS calculated for C25H14F7N5: 517.11, found 518.15 (M+H)+.

Provenance & Evidence