Hydrochloric Acid → HCID 67053834, compound

Participants

Reaction Steps

The crude product from step 5 (5)-tert-butyl 3-(7-carbamoyl-2-(3-fluorophenyl)thieno[2,3-d]pyridazin-4-ylamino)piperidine-1-carboxylate was treated with HCl (4N in dioxane, 3 mL) at room temperature for 30 min. Then the solvent was removed under reduced pressure and the residue was purified with HPLC to obtain the final compound (S)-2-(3-fluorophenyl)-4-(piperidin-3-ylamino)thieno[2,3-d]pyridazine-7-carboxamide. HPLC-MS tR=1.27 min (UV254 nm); mass calculated for formula C18H18FN5OS 371.1, observed LCMS m/z 372.1 (M+H).

Provenance & Evidence