Sulfuric acid magnesium salt (1:1) → HCID 87424661, compound

Participants

Reaction Conditions

Reaction Steps

6-Methoxynicotinaldehyde, (a-1), (20.0 g, 146 mmol) and (R)-(+)-2-methyl-2-propanesulfinamide, (a-2), (21.2 g, 175 mmol) were dissolved in chloroform (140 mL) and PPTS (1.8 g, 7.3 mmol), magnesium sulfate (17.6 g, 146 mmol) and copper(II)sulfate (46.6 g, 292 mmol) were added. The mixture was heated to 65° C. overnight. The material was allowed to cool and was filtered through a Solka Floc pad and concentrated under vacuum. The material was purified by flash chromatography on silica gel gradient eluted with 0-40% EtOAc in hexane affording the product (1-A). HPLC/MS: 241.0 (M+1); Rt=2.84 min.

Provenance & Evidence