2-Chloro-5-fluoropyrimidine → HCID 86720123, compound

HRID 2408550Notes

Reaction equation

HRID 2408550 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.Cl[C:28]1[N:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=1>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:28]5[N:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

3

Reactant 2

HCID 5834662-Chloro-5-fluoropyrimidineHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 86720123HCID 86720123, compound

Procedure

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-chloro-5-fluoro-pyrimidine following a procedure analogous to that described for Intermediate 12. LC (method 2): tR=1.03 min; Mass spectrum (ESI+): m/z=455 [M+H]+.

Sources & evidence

ORD record
ord-c6ff5e4f764d4f38843c0c0ea6c6c671
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

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