4-Cyano-3-methoxyphenylboronic acid → HCID 86720127, compound

HRID 2408554Notes

Reaction equation

HRID 2408554 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[C:27]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][C:30]=1[O:38][CH3:39])#[N:28]>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:32]5[CH:33]=[CH:34][C:29]([C:27]#[N:28])=[C:30]([O:38][CH3:39])[CH:31]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

3

Reactant 2

HCID 450912364-Cyano-3-methoxyphenylboronic acidHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 86720127HCID 86720127, compound

Procedure

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4-cyano-3-methoxy-phenylboronic acid following a procedure analogous to that described for Intermediate 6. LC (method 6): tR=1.18 min; Mass spectrum (ESI+): m/z=490 [M+H]+.

Sources & evidence

ORD record
ord-e5fded8698344083b8de8586851e4eba
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

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