Cesium carbonate → HCID 50991732, compound

HRID 240856Notes

Reaction equation

HRID 240856 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:25]4[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=4)=[CH:15][N:16]3[C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.Cl[CH2:34][CH2:35][N:36]([CH3:38])[CH3:37].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH3:37][N:36]([CH3:38])[CH2:35][CH2:34][O:31][C:28]1[CH:29]=[CH:30][C:25]([C:14]2[C:13]3[C:17](=[CH:18][C:10]([C:6]4[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=4)=[CH:11][CH:12]=3)[N:16]([C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)[CH:15]=2)=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 50991730HCID 50991730, compound

Product 1

HCID 50991732HCID 50991732, compound

Procedure

The target compound was prepared as in Example 18 using 4-(6-(3-nitrophenyl)-1-(pyridin-4-yl)-1H-indol-3-yl)phenol (32 mg, 0.079 mmol), 2-chloro-N,N-dimethylethylamine hydrochloride (34 mg, 0.237 mmol) and cesium carbonate (154 mg, 0.237 mmol).

Sources & evidence

ORD record
ord-d3d54aa761b24484b23407a1da5ba460
Source dataset
uspto-grants-2014_02
Patent number
US08648089B2

Reaction notes

Loading…