4-Fluoro-2,6-dimethylbenzonitrile → HCID 86720139, compound

HRID 2408566Notes

Reaction equation

HRID 2408566 reaction equation
[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH3:27][C:28]1[CH:35]=[C:34](F)[CH:33]=[C:32]([CH3:37])[C:29]=1[C:30]#[N:31]>>[CH3:1][O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([O:25][C:34]5[CH:33]=[C:32]([CH3:37])[C:29]([C:30]#[N:31])=[C:28]([CH3:27])[CH:35]=5)[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

Participants

3

Reactant 2

HCID 404271214-Fluoro-2,6-dimethylbenzonitrileHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 86720139HCID 86720139, compound

Procedure

The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2,6-dimethyl-4-fluoro-benzonitrile following a procedure analogous to that described for Intermediate 12.

Sources & evidence

ORD record
ord-6b1cbccc83ee499aa1162b33d48ec043
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

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