HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-2-methylbenzo[d]oxazole → HCID 86720146, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-2-methylbenzo[d]oxazole | HCID 10036077 | — |
| Reactant | (2-Methyl-1,3-benzoxazol-6-yl)boronic acid | HCID 55262500 | — |
| Reactant | [(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester | HCID 86720104 | — |
| Product | HCID 86720146 | HCID 86720146 | — |
Reaction Steps
The title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-methyl-benzoxazol-6-boronic acid (prepared from 6-bromo-2-methyl-benzoxazole in analogy to the procedure described for Intermediate 46) following a procedure analogous to that described for Intermediate 6. LC (method 3): tR=0.65 min; Mass spectrum (ESI+): m/z=490 [m+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815864B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-f34d3e70c9ab43ce9345b574df464406 |
| Source note | uspto-grants-2014_08 |