HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-7-Fluoro-1-[(S)-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran-6-yloxy]-2,3-dihydro-1H-inden-4-ylboronic acid → {(S)-6-[(R)-7-Fluoro-4-(3-methyl-benzo[d]isoxazol-6-yloxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-7-Fluoro-1-[(S)-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran-6-yloxy]-2,3-dihydro-1H-inden-4-ylboronic acid | HCID 86720141 | — |
| Reactant | 3-Methyl-1,2-benzisoxazol-6-ol | HCID 135497890 | — |
| Product | {(S)-6-[(R)-7-Fluoro-4-(3-methyl-benzo[d]isoxazol-6-yloxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86720149 | — |
Reaction Steps
The title compound is prepared from (R)-7-fluoro-1-[(S)-3-methoxycarbonylmethyl-2,3-dihydrobenzofuran-6-yloxy]-2,3-dihydro-1H-inden-4-ylboronic acid and 3-methyl-benzo[d]isoxazol-6-ol following a procedure analogous to that described for Intermediate 6. LC (method 3): tR=0.66 min; Mass spectrum (ESI+): m/z=490 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815864B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-0f3bfff9533a4853ada540e45154fd6b |
| Source note | uspto-grants-2014_08 |