2-Fluoro-5-(trifluoromethoxy)benzonitrile → HCID 86720152, compound

HRID 2408582Notes

Reaction equation

HRID 2408582 reaction equation
C[O:2][C:3](=[O:26])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([OH:25])[CH:20]=[CH:21][C:22]=4[F:24])[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.F[C:28]1[CH:35]=[CH:34][C:33]([O:36][C:37]([F:40])([F:39])[F:38])=[CH:32][C:29]=1[C:30]#[N:31]>>[C:30]([C:29]1[CH:32]=[C:33]([O:36][C:37]([F:40])([F:39])[F:38])[CH:34]=[CH:35][C:28]=1[O:25][C:19]1[CH:20]=[CH:21][C:22]([F:24])=[C:23]2[C:18]=1[CH2:17][CH2:16][C@H:15]2[O:14][C:12]1[CH:11]=[CH:10][C:9]2[C@H:5]([CH2:4][C:3]([OH:26])=[O:2])[CH2:6][O:7][C:8]=2[CH:13]=1)#[N:31]

Participants

3

Reactant 2

HCID 52210952-Fluoro-5-(trifluoromethoxy)benzonitrileHCID 86720104[(S)-6-((R)-7-Fluoro-4-hydroxyindan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester

Product 1

HCID 86720152HCID 86720152, compound

Procedure

The methyl ester of the title compound is prepared from {(S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-fluoro-5-trifluoromethoxy-benzonitrile following a procedure analogous to that described for Intermediate 12. The title compound is obtained after saponification of the methyl ester as described for Example 1. LC (method 2): tR=1.16 min; Mass spectrum (ESI+): m/z=530 [M+H]+.

Sources & evidence

ORD record
ord-cadfbf585a4b44beb4e92a47f3c56753
Source dataset
uspto-grants-2014_08
Patent number
US08815864B2

Reaction notes

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