2-Propanol, reaction products with ammonia, distn. residues → HCID 50991926, compound

HRID 240865Notes

Reaction equation

HRID 240865 reaction equation
C(O)(C)C.[NH3:5].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-:31])=[O:30])[CH:24]=4)=[CH:20][CH:21]=3)[N:16]([C:32]3[CH:37]=[CH:36][N:35]=[C:34](S(C)=O)[N:33]=3)[CH:15]=2)=[CH:10][CH:9]=1>>[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([N+:29]([O-:31])=[O:30])[CH:24]=4)=[CH:20][CH:21]=3)[N:16]([C:32]3[CH:37]=[CH:36][N:35]=[C:34]([NH2:5])[N:33]=3)[CH:15]=2)=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 183319422-Propanol, reaction products with ammonia, distn. residuesHCID 50991925HCID 50991925, compound

Product 1

HCID 50991926HCID 50991926, compound

Conditions

Temperature
100 °C

Procedure

2.0 M ammonia isopropanol solution (2 mL) was added to 3-(4-methoxyphenyl)-1-(2-(methylsulfinyl)pyrimidin-4-yl)-6-(3-nitrophenyl)-1H-indole (90 mg) and then stirred at 100° C. for 3 hours in a sealed state. After cooling to room temperature, thus produced solid was filtered. After washing with isopropanol and then drying, the target compound (50 mg) was obtained as white solid.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthus produced solid was filtered
  3. washAfter washing with isopropanol
  4. customdrying

Sources & evidence

ORD record
ord-07168389584b4de7bb716579fa08206b
Source dataset
uspto-grants-2014_02
Patent number
US08648089B2

Reaction notes

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