反应详情

温度

120 °C

6-(3-Bromo-6-(4-methoxyphenyl)-1H-indol-1-yl)-N-methylpyrimidin-4-amine (50 mg, 0.074 mmol), K3PO4 (47.1 mg, 0.222 mmol) and 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (27 mg, 0.111 mmol) were dissolved in dimethylformamide (2 mL) and then Pd(PPh3)4 (12.83 mg, 0.011 mmol) was added. After stirring at 120° C. for 3 hours, followed by addition of ethyl acetate and water, the reaction solution was filtered using a diatomite pad. The aqueous layer was extracted with ethyl acetate and the collected organic layer was washed with brine and then concentrated under reduced pressure by drying with magnesium sulfate. The residue was purified by chromatography (silica gel, EtOAc:hexane=1:10→1:4→1:2). The target compound was obtained as brown solid.

1. filtrationthe reaction solution was filtered
2. extractionThe aqueous layer was extracted with ethyl acetate
3. washthe collected organic layer was washed with brine
4. concentrationconcentrated under reduced pressure
5. dry with materialby drying with magnesium sulfate
6. customThe residue was purified by chromatography (silica gel, EtOAc:hexane=1:10→1:4→1:2)
7. customThe target compound was obtained as brown solid