Ethyl 3-cyano-2,2-bis(4-fluorophenyl)propanoate → 3,3-Bis(4-fluorophenyl)pyrrolidin-2-one

Participants

Reaction Steps

A solution of the product from Example 14A (20 mg, 0.063 mmol) in acetic acid (4 mL) was added to PtO2 (4.00 mg, 0.018 mmol) in a 50 mL pressure bottle and stirred at room temperature for 12 hours under hydrogen (30 pounds per square inch). The mixture was filtered through a nylon membrane and then concentrated to obtain solid. The solid was slurried in 5% ethyl acetate/hexanes, filtered and dried to give the title compound. MS (DCI+) m/z 274 (M+H)+.

Provenance & Evidence