HCID 67386829, compound → HCID 53390115, compound

Participants

Reaction Conditions

Reaction Steps

A 50 mL pressure bottle was charged with tetrahydrofuran (10 mL), the product of Example 23E (0.500 g, 0.913 mmol) and 20% Pd(OH)2—C, wet (0.100 g, 0.712 mmol). The reaction mixture was stirred at 50° C. under an atmosphere of 30 psi H2 for 15 minutes. The mixture was filtered through a nylon membrane and concentrated in vacuo. The crude product was purified by chromatography on silica gel (Analogix Intelliflash 280; 2N NH4OH in CH3OH/CH2Cl2, 2:98, eluant) to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.30-7.21 (m, 4H), 7.15-7.05 (m, 4H), 4.17 (s, 2H), 3.45-3.24 (m, 7H), 2.66 (d, J=3.6, 4H), 2.55-2.46 (m, 2H), 1.74-1.60 (m, 2H); MS (DCI+) m/z 414 (M+H)+.

Provenance & Evidence