HCID 67387134, compound → HCID 53390116, compound

Participants

Reaction Conditions

Reaction Steps

A 50 mL pressure bottle was charged with tetrahydrofuran (10 mL), the product from Example 24A (0.450 g, 0.904 mmol) and 20% Pd(OH)2—C, wet (0.090 g, 0.641 mmol). The reaction mixture was stirred at 50° C. under an atmosphere of 30 psi H2 for 15 minutes. The mixture was filtered through a nylon membrane and concentrated in vacuo. The crude product was purified by chromatography on silica gel (Analogix Intelliflash 280; 2N NH4OH in CH3OH/CH2Cl2, 2:98, eluant) to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.36-7.19 (m, 10H), 4.16 (s, 2H), 3.40-3.25 (m, 7H), 2.73 (t, J=6.5, 2H), 2.68-2.59 (m, 4H); MS (DCI+) m/z 364 (M+H)+.

Provenance & Evidence