Thionyl Chloride → HCID 58201184, compound

The above (5-chloro-4-methoxy-6-methylpyridin-3-yl)methanol (520 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (0.38 ml) was then added to the solution under cooling on ice. The resulting mixture was stirred at the same temperature as above for 3 hours. Thereafter, the reaction solution was concentrated, and ethyl acetate was then added to the concentrate. The resulting mixture was washed with saturated sodium bicarbonate solution, water, and saturated saline in this order. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then distilled away. The residue was purified by silica gel chromatography (ethyl acetate-hexane), so as to obtain the title compound (550 mg) as an oily substance.

1. temperatureunder cooling on ice
2. concentrationThereafter, the reaction solution was concentrated
3. additionethyl acetate was then added to the concentrate
4. washThe resulting mixture was washed with saturated sodium bicarbonate solution, water, and saturated saline in this order
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. distillationthe solvent was then distilled away
7. customThe residue was purified by silica gel chromatography (ethyl acetate-hexane)

ORD record

ord-5e978543711743ebb23bdb97b40c842b

Source dataset

uspto-grants-2014_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08815880B2