HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 4-Chloro-6-(methylthio)thieno[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 69671703 | HCID 69671703 | — |
| Product | 4-Chloro-6-(methylthio)thieno[3,2-d]pyrimidine | HCID 59424451 | — |
Reaction Steps
As shown in scheme I, cyclisation of ethyl 3-amino-5-(methylthio)-thiophene-2-carboxylate using formamide and further treatment with phosphorous oxychloride gave 4-chloro-6-(methylthio)thieno[3,2-d]pyrimidine in good yield. Treatment of this 4-chlorocompound with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH gave 3-(6-(methylthio)thieno[3,2-d]pyrimidin-4-ylamino)-5-tert-butylselenophene-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815879B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-05089311e182435a8ecdb5c86edb3b1c |
| Source note | uspto-grants-2014_08 |