HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 86698276, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | HCID 86698277 | HCID 86698277 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86698276 | HCID 86698276 | — |
Reaction Steps
As shown in scheme R, 4-chloro-6,7-dimethoxyquinazoline is reacted with 5-tert-butyl-3-hydroxyselenophene-2-carboxamide in presence of NaOH and DMF to give 3-(6,7-dimethoxyquinazolin-4-yloxy)-5-tert-butylselenophene-2-carboxamide. The 5-tert-butyl-3-hydroxyselenophene-2-carboxamide is prepared in five steps from pinacolone and is described in examples.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815879B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-c31e76c7212e4661a47d52ef1788c92f |
| Source note | uspto-grants-2014_08 |