反应详情

The reaction of 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound a pale yellow color solid, mp 208-212° C. IR (KBr) vmax 3438, 3158, 2949, 1618, 1570, 1385, 1228, 1127, 1027, 859 cm−1; 1H NMR (400 MHz, CDCl3): δ 12.01 (1H, s, exchangeable with D2O), 8.86 (1H, s), 8.72 (1H, s), 7.38 (1H, s), 7.23 (1H, s), 5.37 (2H, br s), 4.32 (2H, t, J=6.4 Hz), 4.01 (3H, s), 3.73 (4H, t, J=4.6 Hz), 2.65 (2H, t, J=7.2 Hz), 2.51-2.52 (4H, m), 2.14 (2H, pentet, J=7.0 Hz), 1.47 (9H, s); 13C NMR (100 MHz, CDCl3): δ 168.9, 168.7, 155.2, 154.5, 153.4, 149.3, 148.2, 147.6, 121.8, 109.8, 109.2, 107.7, 101.4, 67.5, 67.0, 56.2, 55.5, 53.7, 37.2, 32.6, 26.2; LC-MS (negative ion mode): m/z 544, 546 (M−H)−.