反应详情

The reaction of 4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline with 3-amino-5-phenylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as a yellow color solid, mp 236-240° C. IR (KBr) vmax 34369, 3158, 2935, 1635, 1579, 1387, 1321, 1238, 1216, 1145, 1113, 902, 846 cm−1; 1H NMR (400 MHz, DMSO-d6): δ 12.50 (1H, s), 9.16 (1H, s), 8.65 (1H, s), 7.77 (2H, br s), 7.68-7.70 (2H, m), 7.44-7.52 (3H, m), 7.39 (1H, s), 7.26 (1H, s), 4.20 (2H, br s), 3.96 (3H, s), 3.58 (4H, br s), 2.50 (2H, br s), 2.40 (4H, br s), 2.00 (2H, pentet, J=6.5 Hz); LC-MS (positive ion mode): m/z 566, 568 (M+H)+.