Phosphorus oxychloride → 4-Chloro-6-(methylthio)thieno[3,2-d]pyrimidine

Participants

Reaction Steps

A mixture of 6-(methylthio)thieno[3,2-d]pyrimidin-4(3H)-one (900 mg) and phosphorous oxychloride (10 mL) was refluxed for 3 h. The reaction mixture was attained to rt and poured into ice cold water and stirred for 10 min. The precipitated solid was filtered, washed with water and dried to give the product as an off-white color solid (800 mg, 81%), mp 138-140° C. 1H NMR (400 MHz, CDCl3): δ 8.87 (1H, s), 7.25 (1H, s), 2.72 (3H, s).

Provenance & Evidence