3-Amino-5-tert-butylselenophene-2-carboxamide → HCID 86698296, compound

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Reaction Steps

The reaction of 4-chloro-6-(tert-butyl)selenopheno[3,2-d]pyrimidine with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as a white color solid, mp 260-262° C. IR (KBr) vmax 3439, 3173, 2960, 1666, 1605, 1564, 1503, 1458, 1381, 1330, 1244, 1086, 1038, 848, 773 cm−1; 1H NMR (400 MHz, CDCl3): δ 11.32 (1H, s, exchangeable with D2O), 8.75 (1H, s), 8.73 (1H, s), 7.37 (1H, s), 5.34 (2H, br s, exchangeable with D2O), 1.47 (9H, s), 1.46 (9H, s); 13C NMR (100 MHz, CDCl3): δ 171.9, 168.8, 168.5, 164.4, 154.8, 147.8, 122.7, 121.6, 118.4, 108.9, 37.3, 37.1, 32.5, 32.4; LC-MS (positive ion mode): m/z 481, 483, 485 (M+H)+.

Provenance & Evidence