反应详情

The reaction of 4-chloro-6,7-dimethoxy-2-methylquinazoline with 3-amino-5-tert-butylselenophene-2-carboxamide in the presence of DMF/NaOH as described in Example 1 gave title compound as an off-white color solid, mp 266-268° C. 1H NMR (400 MHz, CDCl3): δ 11.95 (1H, br s, exchangeable with D2O), 8.97 (1H, s), 7.32 (1H, s), 7.19 (1H, s), 5.38 (2H, br s, exchangeable with D2O), 4.08 (3H, s), 4.01 (3H, s), 2.70 (3H, s), 1.47 (9H, s); 13C NMR (100 MHz, CDCl3): δ 168.63, 168.60, 162.1, 154.8, 154.5, 149.2, 148.2, 148.1, 121.9, 109.0, 107.4, 107.1, 100.1, 56.2, 56.1, 37.1, 32.5, 26.3; LC-MS (negative ion mode): m/z 445, 447 (M−H)−.