Ammonium Chloride → HCID 86689826, compound

Participants

Reaction Steps

To a solution of 1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde oxime (600 mg, 1.9 mmol) in MeOH (10 mL) was added zinc powder (600 mg, 9.5 mmol) and ammonium chloride (1.0 g, 19 mmol). The suspension was refluxed for 18 h and then the solid was filtered. The filtrate was diluted with DCM (200 mL) and water (50 mL). The organic layer was separated, dried (MgSO4), filtered, and concentrated to afford 503 mg (98%) of (1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanamine as yellow solid which was used in the next step without further purification; MS (ESI) m/z: 302.1 [M+1]

Provenance & Evidence