HCID 86762616, compound → HCID 86762617, compound

Participants

Reaction Steps

To a solution of 6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile (1096 mg, 3.77 mmol) in a solution of NH3/MeOH (7 N, 100 mL) was added Raney nickel (1000 mg), followed by stirring under a hydrogen atmosphere overnight. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford (6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)methanamine (1000 mg, 90%). MS (ESI): m/z=296.1 [M+1]+.

Provenance & Evidence