反应详情

温度

80 °C

A mixture of (±)—N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(1-tosyl-1H-pyrrolo[3,2-c]pyridin-4-yl)ethyl)pyrimidine-2,4-diamine (563 mg, 1.10 mmol) and sodium hydroxide (132 mg, 3.29 mmol) in MeOH (20 mL) and water (50 mL) was stirred at 80° C. for 3 h. The reaction mixture was concentrated in vacuo. The crude product was purified by reverse phase preparative HPLC to afford N2-1-(1H-pyrrolo[3,2-c]pyridin-4-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine: MS (ESI) m/z: 361.2 [M+1]+.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe crude product was purified by reverse phase preparative HPLC