Diisopropylethylamine → HCID 71611282, compound

Participants

Reaction Conditions

Reaction Steps

A sealed-cap vial was charged with 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-pyrimidin-4-amine (60 mg, 0.25 mmol), tert-butyl 5-(1-aminoethyl)-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (93 mg, 0.36 mmol), DIPEA (0.16 mL) and n-BuOH (0.8 mL). The mixture was heated at 115° C. for 72 h. The reaction mixture was concentrated under reduced pressure. The crude mixture was purified by preparative HPLC to afford N2-(1-(1H-pyrrolo[2,3-c]pyridin-5-yl)ethyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine: MS (ESI) m/z: 361.2 [M+1]+.

Provenance & Evidence