2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine → HCID 86762626, compound

Participants

Reaction Steps

The title compound was prepared following the procedure according to Example 9, using (S)-1-(1H-pyrrolo[3,2-b]pyridin-5-yl)ethanamine hydrochloride (referential example 17) and 2-chloro-N-(5-((1R,2R)-2-fluorocyclopropyl)-1H-pyrazol-3-yl)pyrimidin-4-amine (referential example 4) in place of (1H-pyrrolo[3,2-b]pyridin-5-yl)methanamine and 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine (referential example 1), respectively, as starting materials. 1H NMR (400 MHz, DMSO-d6) δ 11.98 (br s, 1H), 11.18 (s, 1H), 9.33 (br s, 1H), 7.79 (d, J=5.6 Hz, 1H), 7.70 (d, J=8.4 Hz, 1H), 7.57 (s, 1H), 7.16 (d, J=8.3 Hz, 1H), 6.93 (br s, 1H), 6.53 (s, 1H), 6.40 (br s, 1H), 6.10 (br s, 1H), 5.21 (s, 1H), 4.90 (d, J=65.8 Hz, 1H), 2.10-1.99 (m, 1H), 1.49 (d, J=6.9 Hz, 3H), 1.33 (s, 1H), 1.24 (s, 1H); MS (ESI) m/k: 379.2 [M+1]+.

Provenance & Evidence