反应详情

To a solution of 7-methoxyindole (1 eq) in DMF cooled in an ice bath was added NaH (60% dispersion in oil, 1.2 eq). The reaction was stirred for 1 hr at room temperature then recooled in an ice bath. Benzenesulfonyl chloride (1.1 eq) was added then the reaction was stirred for 2 hrs at room temperature. Water/ethyl acetate were added and the ethyl acetate layer was washed repeatedly (3×) with water. The ethyl acetate layer was concentrated and evaporated to dryness.

1. customthen recooled in an ice bath
2. stirringthe reaction was stirred for 2 hrs at room temperature
3. washthe ethyl acetate layer was washed repeatedly (3×) with water
4. concentrationThe ethyl acetate layer was concentrated
5. customevaporated to dryness