tert-butyl N-(methylcarbamothioyl)carbamate → HCID 86661858, compound

HRID 2409121Notes

Reaction equation

HRID 2409121 reaction equation
CO[C:3](=[O:18])[CH2:4][C@:5]1([NH2:17])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=2)[CH2:7][CH2:6]1.[CH3:19][NH:20][C:21]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=S>>[CH3:19][N:20]1[C:3](=[O:18])[CH2:4][C@@:5]2([C:13]3[C:8](=[CH:9][CH:10]=[C:11]([N+:14]([O-:16])=[O:15])[CH:12]=3)[CH2:7][CH2:6]2)[N:17]=[C:21]1[NH:23][C:24](=[O:30])[O:25][C:26]([CH3:28])([CH3:27])[CH3:29]

Participants

3

Reactant 2

HCID 57496573tert-butyl N-(methylcarbamothioyl)carbamateHCID 66727416HCID 66727416, compound

Product 1

HCID 86661858HCID 86661858, compound

Procedure

Starting from ((S)-1-amino-6-nitro-indan-1-yl)-acetic acid methyl ester and tert-butyl [(methylamino)carbonothioyl]carbamate, the product tert-butyl [(1S)-1′-methyl-6-nitro-6′-oxo-2,3,5′,6′-tetrahydro-1′H-spiro[indene-1,4′-pyrimidin]-2′-yl]carbamate was obtained as pale brown solid. MS (ESI): m/z=373.1 [M−H]−.

Sources & evidence

ORD record
ord-e7c78b13408541d3bd2033a093a2cb53
Source dataset
uspto-grants-2014_08
Patent number
US08815881B2

Reaction notes

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