HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyanocyclopropanecarboxylic acid → HCID 57496990, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyanocyclopropanecarboxylic acid | HCID 2733259 | — |
| Reactant | [(R)-4-(3-amino-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57496606 | — |
| Product | HCID 57496990 | HCID 57496990 | — |
Reaction Steps
The coupling of [(R)-4-(3-amino-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate F1) and 1-cyano-cyclopropanecarboxylic acid followed by deprotection of the intermediate yielded the title compound as a white solid. MS (ESI): m/z=354.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-cc0b9599c13f4e4ba3fb209d9d313793 |
| Source note | uspto-grants-2014_08 |