1-(Trifluoromethyl)cyclopropane-1-carboxylic acid → HCID 66727600, compound

Participants

Reaction Steps

The coupling of tert-butyl [(1S)-6-amino-1′-methyl-6′-oxo-2,3,5′,6′-tetrahydro-1′H-spiro[indene-1,4′-pyrimidin]-2′-yl]carbamate (intermediate F6) and 1-trifluoromethyl-cyclopropanecarboxylic acid followed by deprotection of the intermediate yielded the title compound as a white solid. MS (ESI): m/z=381.2 [M+H]+.

Provenance & Evidence