HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-1H-pyrazol-5-amine → HCID 57497069, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-1H-pyrazol-5-amine | HCID 520721 | — |
| Reactant | [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57497154 | — |
| Product | HCID 57497069 | HCID 57497069 | — |
Reaction Steps
The coupling of [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate E8) and 2,5-dimethyl-2H-pyrazol-3-ylamine according to procedure B followed by deprotection yielded the title compound as a black waxy solid. MS (ESI): m/z=373.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-0edb1579f1514e2bb61b6d9d59ece64e |
| Source note | uspto-grants-2014_08 |