HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-methyl-2,3-dihydro-1H-inden-1-one → (6S)-2-Amino-6-(2-fluoro-5-(7-methyl-2,3-dihydro-1H-inden-1-ylamino)phenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-methyl-2,3-dihydro-1H-inden-1-one | HCID 589669 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | (6S)-2-Amino-6-(2-fluoro-5-(7-methyl-2,3-dihydro-1H-inden-1-ylamino)phenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one | HCID 57497000 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 7-methyl-indan-1-one using decaborane yielded a mixture of epimers of the title compound as a colorless waxy solid. MS (ESI): m/z=409.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-d30cbc8cbb944c5691bcc88000ca3b29 |
| Source note | uspto-grants-2014_08 |