HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethoxy)aniline → HCID 57497011, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethoxy)aniline | HCID 73754 | — |
| Reactant | [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57497154 | — |
| Product | HCID 57497011 | HCID 57497011 | — |
Reaction Steps
The coupling of [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate E8) and o-(trifluoromethoxy)phenylamine according to procedure A followed by deprotection yielded the title compound as a white solid. MS (ESI): m/z=439.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-8ba0a056df5c420eb508bca4ab839af6 |
| Source note | uspto-grants-2014_08 |