HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetaldehyde → (S)-2-Amino-6-(2-fluoro-5-(2,2,2-trifluoroethylamino)phenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetaldehyde | HCID 65564 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | (S)-2-Amino-6-(2-fluoro-5-(2,2,2-trifluoroethylamino)phenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one | HCID 57497012 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and trifluoro-acetaldehyde using decaborane yielded the title compound as a colorless waxy solid. MS (ESI): m/z=361.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-02f79576d5bb44e2a543be3da78e8ca4 |
| Source note | uspto-grants-2014_08 |