HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoroaniline → HCID 57497039, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoroaniline | HCID 9709 | — |
| Reactant | [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57497154 | — |
| Product | HCID 57497039 | HCID 57497039 | — |
Reaction Steps
The coupling of [(S)-4-(5-bromo-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate E8) and 2,4-difluorophenylamine according to procedure A followed by deprotection yielded the title compound as a white solid. MS (ESI): m/z=391.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-446644b488974888a9ecf8aff4566558 |
| Source note | uspto-grants-2014_08 |