HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine-2-carbaldehyde → (S)-2-Amino-6-{2-fluoro-5-[(pyrimidin-2-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine-2-carbaldehyde | HCID 13751953 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | (S)-2-Amino-6-{2-fluoro-5-[(pyrimidin-2-ylmethyl)-amino]-phenyl}-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497088 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and pyrimidin-2-carbaldehyde using decaborane yielded the title compound as a white foam. MS (ESI): m/z=371.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-00c28f6bf30747099e91708999f8d18f |
| Source note | uspto-grants-2014_08 |