HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 13974581, compound → HCID 66727426, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 13974581 | HCID 13974581 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | HCID 66727426 | HCID 66727426 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and rac-acetic acid 5-oxo-bicyclo[2.2.1]hept-2-yl ester (prepared as in J. Meinwald et al., Tetrahedron 1962, 18, 815-820) using decaborane yielded a mixture of isomers of the title compound as a white foam. MS (ESI): m/z=431.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-7e5664eb777f492291a8c5f2cdb8d71a |
| Source note | uspto-grants-2014_08 |