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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2409182Generated: October 31, 2026

HCID 12927389, compound → HCID 57497070, compound

https://huagongshe.com/reaction/2409182

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 12927389HCID 12927389—
Reactant(S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-oneHCID 57497157—
ReactantHCID 178419135HCID 178419135—
ProductHCID 57497070HCID 57497070—

Reaction Steps

The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and rac-3-ethyl-indan-1-one (prepared according to Kousik K., J. Am. Chem. Soc. 2005, 127, 16042) using decaborane yielded a mixture of isomers of the title compound as a white solid. MS (ESI): m/z=423.3 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08815881B2
Source datasetuspto-grants-2014_08
ORD IDord-18afc4a6b6f14df3bb1022691ac3c742
Source noteuspto-grants-2014_08