Lithium Hydroxide → HCID 57516104, compound

Participants

Reaction Steps

To a solution of (1S,3R,5R,6S)-2-[3-((S)-2-Amino-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-4-yl)-4-fluoro-phenylamino]-3-hydroxy-bicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester (example 100, 0.05 mmol) in THF (1 ml), MeOH (0.3 ml) and H2O (0.3 ml) was added LiOH (1N, 0.1 mmol) and the reaction mixture was stirred at room temperature for 4 h. The mixture was concentrated in vacuo, the residue diluted with aqueous HCl (0.5 N) until pH=5 and evaporated again. The solid residue was triturated with dichloromethane/MeOH (10:1), filtered and the filtrate was concentrated in vacuo to yield a mixture of isomers of the title compound as a white solid. MS (ESI): m/z=419.3 [M+H]+.

Provenance & Evidence