Hydrochloric Acid → HCID 57497103, compound

Participants

Reaction Steps

To a solution of (S)-2-amino-6-(5-(1-benzyl-1H-pyrazol-5-ylamino)-2-fluorophenyl)-3,5,5,6-tetramethyl-5,6-dihydropyrimidin-4(3H)-one (example 107, 0.02 mmole) in methanol (1 ml) was added a solution of aqueous 4M HCl in 1,4-dioxane (0.25 ml) and Pd/C (10%, 3 mg) under argon. The reaction mixture was hydrogenated at 1 atm H2 for 2 h, filtered over Decalite and the residue was washed with methanol. The filtrate was concentrated in vacuo and the residue purified by flash chromatography on NH2-silica using a gradient of dichloromethane/methanol to yield the title compound as a colorless waxy solid. MS (ESI): m/z=345.2 [M+H]+.

Provenance & Evidence