HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyano-borohydride → HCID 57497093, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyano-borohydride | HCID 498716 | — |
| Reactant | 2-Acetyl-4,5-dimethylthiazole | HCID 2756272 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | HCID 57497093 | HCID 57497093 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 1-(4,5-dimethyl-thiazol-2-yl)-ethanone with zinc-modified cyanoborohydride yielded a mixture of epimers of the title compound as a colorless solid. MS (ESI): m/z=418.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-b7c13a63537c4a7c85d5a9cc8fad1b64 |
| Source note | uspto-grants-2014_08 |