HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyano-borohydride → HCID 57497063, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyano-borohydride | HCID 498716 | — |
| Reactant | 2-Acetylbenzothiazole | HCID 539568 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Product | HCID 57497063 | HCID 57497063 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 1-benzothiazol-2-yl-ethanone with zinc-modified cyanoborohydride yielded a mixture of epimers of the title compound as a colorless solid. MS (ESI): m/z=440.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-9b3509e0538745fc9775c01b6c63d363 |
| Source note | uspto-grants-2014_08 |