Lithium Hydroxide → HCID 66727679, compound

Participants

Reaction Steps

To a solution of (S)-methyl-3-(3-(2-amino-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydropyrimidin-4-yl)-4-fluorophenylamino)-4-methoxybenzoate (example 122, 0.05 mmol) in THF (1 ml), MeOH (0.3 ml) and H2O (0.3 ml) was added LiOH (1N, 0.1 mmole) and the reaction mixture was stirred at room temperature for 12 h. The mixture was concentrated in vacuo and the residue diluted with aqueous HCl (0.5N) until pH=5 and extracted with dichloromethane. The organic phase was dried, evaporated and the residue triturated with Et2O to give the title compound as a white solid. MS (ESI): m/z=429.2 [M+H]+.

Provenance & Evidence