Lithium Hydroxide → HCID 66727676, compound

Participants

Reaction Steps

To a solution of (S)-methyl 4-(3-(2-amino-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydropyrimidin-4-yl)-4-fluorophenylamino)-3-methoxybenzoate (example 123, 0.05 mmol) in THF (1 ml), MeOH (0.3 ml) and H2O (0.3 ml) was added LiOH (1N, 0.1 mmole) and the reaction mixture was stirred at room temperature for 12 h. The mixture was concentrated in vacuo, the residue was dissolved in aqueous HCl (0.5N) until pH=5 and extracted with dichloromethane. The organic phase was separated, dried over Na2SO4 and evaporated to yield a white solid. The solid material was triturated with Et2O, filtered and dried to yield the title compound as a white solid. MS (ESI): m/z=429.2 [M+H]+.

Provenance & Evidence