HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Oxo-indan-4-carboxylic acid → HCID 66727782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Oxo-indan-4-carboxylic acid | HCID 12542206 | — |
| Reactant | (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one | HCID 57497157 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Product | HCID 66727782 | HCID 66727782 | — |
Reaction Steps
The reductive amination of (S)-2-amino-6-(5-amino-2-fluoro-phenyl)-3,5,5,6-tetramethyl-5,6-dihydro-3H-pyrimidin-4-one (intermediate J) and 1-oxo-indan-4-carboxylic acid using decaborane yielded a mixture of epimers of the title compound as a light yellow foam. MS (ESI): m/z=439.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-afa938b71e1a48c880ef34be6e5a3281 |
| Source note | uspto-grants-2014_08 |