HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid → HCID 56654775, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid | HCID 2760712 | — |
| Reactant | [(S)-4-(5-amino-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester | HCID 57496584 | — |
| Product | HCID 56654775 | HCID 56654775 | — |
Reaction Steps
The coupling of [(S)-4-(5-amino-2-fluoro-phenyl)-1,4,5,5-tetramethyl-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester (intermediate F2) and (R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propionic acid followed by deprotection of the intermediate yielded the title compound as a white solid. MS (ESI): m/z=419.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08815881B2 |
| Source dataset | uspto-grants-2014_08 |
| ORD ID | ord-ac84ae90cbdf421c8b274a0267972fe1 |
| Source note | uspto-grants-2014_08 |